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Chondroitinase Enzymes

Chondroitinase AC-I and Chondroitinase B Enzymes

High-activity, high-purity enzymes from native strains of Flavobacterium heparinum 

The elimination reaction of these enzymes forms end-chain unsaturated uronic acids that absorb at 232nM; this feature helps monitor substrate depolymerisation and for the analysis of the disaccharide composition of chondroitin sulphate or dermatan sulphate  

Enzyme activity is given in international units (IU); one unit of activity is the amount of enzyme that forms 1.0 micromole of unsaturated uronic acid per minute acting on chondroitin sulphate for (AC-I) or dermatan sulphate (for the B enzyme) (see data sheet).

Enzymes are supplied as frozen solutions, stabilised by 0.1% to 0.2% BSA and delivered on dry ice by international courier.                 

Chondoitinase AC-I degrades chondroitin sulphate A and chondroitin sulphate C

Susecptible Linkages: 

GalNAc, (4SO3 or 6 SO3) 1-4 GlcA

enzyme also acts on hyaluronic acid 

Chondroitinase B degrades dermatan sulphate acts specifically on the amino sugar-iduronic acid linkage in dermatan sulphate

Susceptible linkage:  

GalNAc, 4SO3 1-4 IdoA

Product Catalog No Qty £
  1. Chondroitinase Enzymes
    Chondroitinase AC CDAC-ENZ 1.0IU
    185.00 Enquire Now
    Chondroitinase B CDB-ENZ 1.0IU
    588.50 Enquire Now

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