Chondroitin and Dermatan Sulphate Polymers

Description

We offer a series of chondroitin sulphates (CS) and dermatan sulphates (DS) that cover the principal isomers found in mammalian tissues. We supply CS-A (GlcA – GalNAc,4S), CS-C (GlcA – GalNAc,6S), CS-E (GlcA – GalNAc 4S, 6S) and DS (IdoA – GalNAc,4S; also called CS-B).

References:

Mizumoto, S., Yamada, S. & Sugahara, K. (2015) Molecular interactions between chondroitin–dermatan sulfate and growth factors/receptors/matrix proteins. (2105) Current Opinion in Structural Biology. 34, 35-42

Derbal, I., Lortat-Jacob, H. & Kwok, J. (2017) Chondroitin sulfates and their binding molecules in the central nervous system. Glycoconjugate J. 34, 363 - 376

Application. 

Research in cell growth and development protein binding studies.

Chondroitin Sulphate (CS) and Dermatan Sulphate (DS) are common constituents of the pericellular environment of most mammalian organs and tissues. They are well-known as structural elements of the ECM but over the past 10 years or so peer-reviewed papers have revealed their importance in cell growth and differentiation, particularly in the embryonic nervous system. The effects of CS and DS on cell development are dependent on interactions with peptide growth factors and morphogenic proteins.  These interactions often require specific molecular characteristics of the CS and DS chains in which relatively rare disulphated disaccharides (diCS-E and/or diDS-E units) are key components. To aid research in this field we offer a series of CS and DS polymers that cover the principal isomers found in mammalian tissues. These products also have application in protein binding studies or competitive processes, especially involving comparisons between the effects of different levels and patterns of sulphation on the specificity of interactions and influences on protein conformation and activity. 

Please email [email protected] for further info or to place an order